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Major depressive disorder presents distinct challenges across pediatric, adult, and geriatric populations, particularly when symptoms persist despite initial treatment. These downloadable slides explore age-specific approaches to screening, diagnosis, and treatment selection, with an emphasis on clinical decisions about switching antidepressants or initiating adjunctive therapies. Learners will examine emerging evidence, pharmacologic and nonpharmacologic treatment options, and practical considerations for managing residual symptoms, treatment resistance, and medication safety across the lifespan.